MediShield™ Biocompatible Coatings
MediShield™ Biocompatible Coatings
For implantable / indwelling medical devices and biosensors,
biofouling is a major problem that can lead to device malfunctioning, foreign body reaction, and infection.
The biofouling process starts with protein binding to the surface,
followed by cells attaching to the proteins on the surface.
To mitigate biofouling, a hydrogel coating is used to resist protein binding,
as protein binding is minimized, cell attachment is reduced as a result, and biofouling is therefore mitigated.
This will allow the devices to work better and safer in vivo.
Medical Surface has developed the MediShield™ Biocompatible Coatings
(an innovative hydrogel coating) to effectively limit the Foreign Body Response and
to significantly extend the life of implanted devices and biosensors.
Exceptionally low protein binding
The binding of host proteins to the surface of implanted medical devices is recognized to be the beginning
of the biofouling process.
The MediShield™ Biocompatible Coating has been specifically designed to resist protein adsorption
and has significantly lower protein binding compared to traditional coated hydrogels.
Resistance to cellular adhesion
The adsorption of host proteins onto the implant surface, including complement related proteins
leads to an initial inflammatory response at the implant site.
Monocytes and macrophages recruit other cells, resulting in the adhesion of cells to the implanted device.
The MediShield™ Biocompatible Coating has been shown to resist adhesion of cells during prolonged period
of contacting blood samples.
Resistance to bacterial adhesion
Permeability to glucose
Biosensor coatings not only need to create an effective barrier against host cells and proteins,
but also need to be permeable to host analytes that are being measured.
The MediShield™ Biocompatible Coating has been shown to be highly permeable to glucose
which is essential to glucose biosensor functionality.
In this test, uncoated and coated dialysis membranes (3.5kD MWCO) were compared side-by-side
for permeability to glucose.
MediShield™ Biocompatible Coating was found to have no significant effect on the permeation of glucose
across the dialysis membrane.